What condition is most likely to result in unequal pupils?

The condition most likely to result in unequal pupils is cerebrovascular accident (CVA), commonly known as a stroke. When a CVA occurs, it can lead to changes in neurological function, which may manifest as specific eye signs, including unequal pupil size, or anisocoria. This happens because a stroke can damage areas of the brain that control pupil response, resulting in one pupil being larger or smaller than the other. The timing and severity of these pupil changes can be critical in diagnosing and treating the underlying neurological issues.

In contrast, while glaucoma can affect vision and may lead to other ocular symptoms, it usually does not cause unequal pupils. Likewise, a concussion may have various ocular symptoms, but it does not typically cause significant differences in pupil size. Retinal detachment is a serious eye condition that primarily affects vision but does not generally lead to changes in pupil size. The distinct mechanism of impairment in a CVA makes it the most relevant choice for the question regarding unequal pupils.